New paper published in the journal Drug Metabolism and Disposition: Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
Our Pharmaceutical Director, Dr Gerry Kenna co-authored the paper with Dr Jack Uetrecht, Professor of Pharmacy and Medicine at the University of Toronto and the Canada Research Chair in Adverse Drug Reactions
Many new medicines cause undesired side effects in humans that are not predicted by the drug safety studies performed currently. This review focuses on liver injury, which is an especially important human adverse drug effect. It highlights both the promising progress made in developing human-relevant in vitro methods that can anticipate and reduce drug induced liver injury risk, and outstanding challenges which remain to be addressed.
Our Research Consultant, Dr Pandora Pound, gives a fascinating insight into the introduction of the use of systematic reviews in preclinical animal research, in which she played an instrumental role.
Systematic reviews have become accepted as powerful tools that should be deployed routinely to improve the quality of the evidence base in clinical research. Although their use is not yet routine in preclinical research, they have been instrumental in provoking debate about the reliability, validity, and value of preclinical animal research.
The second newsletter from the Alliance for Human Relevant Science is now published here
and the April newsletter from SYRCLE (SYstematic Review Center for Laboratory animal Experimentation) in the Netherlands is here
We are delighted that Dr Pandora Pound, PhD has joined us as our new Research Consultant. Pandora has been conducting research since 1990 and has worked within universities and medical schools throughout London and the South West, mainly in the field of public health. She was an early proponent of the need for systematic reviews of animal research and has published widely on the need for an evidence-based approach in this field. Two of her seminal publications include “Where is the evidence that animal research benefits humans?” and “Is animal research sufficiently evidence based to be a cornerstone of biomedical research?”. In 2017 she left academia to focus on this issue and to work towards more human-relevant approaches to the development and testing of medicines.