Safer Medicines Trust collaborating with FRAME

Safer Medicines Trust collaborating with FRAME

FRAME has recently published an analysis of the value of studies in dogs for predicting the safety of human medicines. The salient feature of this study is the use of appropriate statistical metrics, which have not previously been applied to such data. The results shine a new light on our reliance on dogs for this purpose, suggesting that they contribute little or nothing to ensuring our safety. Read the paper or watch the presentation by lead author Dr Jarrod Bailey.

We look forward to working with FRAME and OpenTox on a new study to assess the value of human in vitro approaches to predict the safety of medicines. Data will kindly be provided by the US Government ToxCast programme, part of the Tox21 initiative, and by the US National Center for Toxicological Research. The study will measure the ability of human in vitro tests to predict drug-induced liver injury (DILI) against the ability of animal tests to do so.

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New paper discusses  in silico New Approach Methodologies (NAMs) and increasing use of ‘big data’ to advance human relevant research

A new paper by Safer Medicines scientific consultant Rebecca Ram, Dr. Domenico Gadaleta of the Mario Negri Institute, Italy and Dr. Tim Allen of the MRC Toxicology Unit, Cambridge discusses the progress of in-silico methods in New Approach Methodologies (NAMs) as well as the increasing need for use of ‘big data’ and artificial intelligence (AI) […]

World Animal Free Research Day

One of our partner charities in the Alliance for Human Relevant Science is Animal Free Research UK. They have initiated an annual World Animal Free Research Day on the anniversary of their founding, 27th May. Our goals are very complementary: Animal Free Research UK’s vision is “To create a world where human diseases are cured faster without animal suffering”, while […]