New review article coauthored by Dr Gerry Kenna published in the journal Clinical Pharmacology & Therapeutics:
Medicines can cause serious unwanted side effects in some patients. These include drug-induced liver injury (DILI), which is poorly predicted by the currently used safety test methods. Assays that focus on human-relevant mechanisms can provide more useful data. One important mechanism is inhibition of a liver cell membrane transport protein called the Bile Salt Export Pump (BSEP). This article reviews the evidence linking BSEP inhibition with DILI and describes methods to evaluate and interpret BSEP inhibition. It also recommends how these data can be used to aid the design and selection of safer medicines. The authors from Safer Medicines Trust, major pharmaceutical companies, universities and biotechnology companies were brought together by the International Transporter Consortium.
This week marks World Alzheimer’s Day (21 Sept) and greater public support than ever for investment in research to provide effective treatments. An estimated 45 million people worldwide suffer with AD and other dementias. It remains one of the world’s biggest killers and has been investigated with substantial global research funding for decades. Public support is […]World Patient Safety Day 2021
World Patient Safety Day was established in 2019 to enhance global understanding of patient safety, increase public engagement in health care safety, and promote global action to prevent and reduce avoidable harm in health care. This year’s theme is “Safe maternal and newborn care” and calls on all stakeholders to accelerate the actions necessary for […]