These consider some of the issues relating to the use of animals in biomedical research:
Animal cancer is not the same as human cancer and substances known to be carcinogenic in one species are not necessarily carcinogenic for other species. Animal models are unable to mimic the complex process of human carcinogenesis, physiology and progression, with the result that they rarely translate into benefits for humans with cancer.
The average rate of translation from animal models to successful clinical cancer trials is less than 8%. Experts in the field are increasingly recommending a reduction in reliance on animal models and the use of new (non-animal) approaches in order to transform cancer drug discovery (Jackson and Thomas 2017), including microdosing in (Phase 0) human trials, in vitro human cell-based assays, in silico (computer) models, increased emphasis on epidemiology (Mak et al 2014), and the use of human tissue models (Jackson and Thomas 2017).
Dr Azra Raza, Professor of Medicine at Columbia University in New York, and Science Adviser to Safer Medicines Trust gives a powerful and moving 13-minute TEDx Talk on the need for human-focused cancer research.
By Rebecca Ram This month marks World Liver Day (held every year on 19 Apr) to raise awareness about diseases of the second largest organ in the body. After the brain, the liver is the most complex organ and is vital to the efficient control of the gastrointestinal (digestive) system. Liver diseases account for approximately […]New Approach Methodologies in COVID-19: systematic review into the neurological effects of SARS-CoV-2 infection presented at SOT (Society of Toxicology) Congress 2022
By Rebecca Ram Launched nearly two years ago, the CIAO project (Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway Framework) involves the collaboration of scientific experts to identify the chemical and biological events involved in the body’s response to the SARS-CoV-2 virus. Expert working groups are established across a number of areas, for […]