These consider some of the issues relating to the use of animals in biomedical research:
Many factors perpetuate animal research, the most obvious of which is tradition. The animal research paradigm is very deeply embedded within research institutions. Laboratories, researchers’ careers, technologies, publication practices and funding streams are now ‘locked-in’ to the paradigm. For example, it is easier and faster to publish papers based on animal research than on human research, and a good publication record will attract funding to continue that research.
Pharmaceutical companies continue to do animal tests because regulators require them to do so and because (despite their lack of reliability) animal tests provide liability protection in court when drugs injure or kill people. Yet most of the animal tests accepted by regulators have never been validated.