Despite resisting scientific scrutiny for decades, animal studies have, over the last twenty years, been revealed by systematic reviews to be poorly conducted and unreliable, with the result that humans have, on occasion, been seriously harmed. Such troubling exposures have prompted several initiatives to improve the quality of animal studies and their reporting, but these have had little impact so far on improving their translation to humans. Could it be that fundamental differences between species constitute an insurmountable problem for biomedical research? Given that transformative human relevant technologies such as organ-chips and organoids are now available, could now be the time for a new paradigm?
The problem Alzheimer’s disease (AD) is a leading cause of death in the UK and along with other dementias, is responsible for almost 11% of all deaths in England.1 More than 209,000 new cases are diagnosed each year across the UK.2 It remains a leading cause of death and disability worldwide3, affecting nearly 50 million […]New paper discusses in silico New Approach Methodologies (NAMs) and increasing use of ‘big data’ to advance human relevant research
A new paper by Safer Medicines scientific consultant Rebecca Ram, Dr. Domenico Gadaleta of the Mario Negri Institute, Italy and Dr. Tim Allen of the MRC Toxicology Unit, Cambridge discusses the progress of in-silico methods in New Approach Methodologies (NAMs) as well as the increasing need for use of ‘big data’ and artificial intelligence (AI) […]